Welcome

Centre for Programmable Biological Matter

OUR MISSION

At the Centre for Programmable Biological Matter (CPBM), our mission is to design and build artificial molecular machines with life-like functionality, pushing the boundaries of bionanoscience. We aim to revolutionize medicine, energy, and environmental sustainability by engineering dynamic, programmable systems that exceed the capabilities of nature. With the power to create nucleic acid and protein structures de novo, we stand at the forefront of a new era where biological matter is not only understood but designed for purpose. Our goal is to turn this vision into reality. We leverage world-class resources, state-of-the-art equipment, and an environment that empowers researchers and innovators to conduct cutting-edge, interdisciplinary research. CPBM fosters a culture of collaboration, uniting diverse expertise and utilising molecular design to accelerate breakthroughs to redefine the future of science and technology.

RESEARCH AREAS

Heddle Lab – Natural Nanomachines

Here we investigate topoisomerases, specifically DNA gyrase, both a fascinating nanomachine and an important target for antibacterial drugs.

Heddle Lab – Artificial Protein Nanostructures

Here we aim to build new artificial protein nanostructures not found in nature.

Heddle Lab – DNA Nanomachines

DNA is not just an information storage molecule it is also a highly programmable structural material that can be easily designed to form useful shapes and even programmable robots.

Bentham Lab – Protein Design

Utilising computational protein design and experimental structural biology to guide the bioengineering of staple crops with enhanced resistance to biotic and abiotic stresses.

Lin Lab – RNA Modification

RNA modification is a way to expand nucleotide structure diversity to fulfil different functions. In the Lin lab, we study mechanisms on how RNA modifying enzymes select their RNA targets by obtaining cryo-electron microscope structures details. This will be the basis for customised RNA modifications for bioengineering purposes.

Latest News

Check out our news page for the latest news and events

CPBM at Astbury Conversation 2026

Earlier this year, members of the Centre for Programmable Biological Matter attended the annual Astbury Conversation conference in Leeds. Dr. Ting-Yu Lin and Prof Jonathan Heddle attended, alongside 2nd year[…]

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CPBM PhDs Present and Win at Biosciences Postgraduate Conference 2026

At this year’s Department of Biosciences Postgraduate Conference and Away Day, the Centre for Programmable Biological Matter was well-represented, from posters to session chairs to research talks. CPBM post-doctoral research[…]

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Prof Jonathan Heddle visits universities across Japan

In his recent trip to Japan, CPBM Director Prof Jonathan Heddle visited colleagues across several universities, to share ideas, opportunities for collaboration and the research taking place at the Centre[…]

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