Artificial Protein

Centre for Programmable Biological Matter

Nature has come up with many different protein folds that have a variety of structural and catalytic functions, but with the advent of AI-based protein design tools, we can create new proteins, previously unseen in nature, with bespoke characteristics and shapes. In our lab, we seek to use both proteins from nature as well as custom, de novo proteins to produce nanoscale devices, protein cages, and other nanostructures for use in a variety of functions.   The rapidly emerging field of de novo protein design provides countless opportunities to explore the interface of de novo protein systems with biological processes to deconstruct and eventually control cellular functions for a desired therapy or cure.