Lin Lab
RNA modification is a way to expand nucleotide structure diversity to fulfil different functions. In the Lin lab, we study mechanisms on how RNA modifying enzymes select their RNA targets by obtaining cryo-electron microscope structures details. This will be the basis for customised RNA modifications for bioengineering purposes.
RNA modification publications:
Biela, AD., Nowak, JS., Biela, AP., Mukherjee, S., Moafineja, S., Maiti, S., Chramiec-Glabik, A., Mehta, R., Jezowski, J., Dobosz, S., Dahar, P., Arluison, V., Wien, F., Indyka, P., Rawski, M., Bujnicki, JM., Lin, T., Glatt, S.
Determining the effects of pseudouridine incorporation on human tRNAs
In: The EMBO Journal. 2025.
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Lin, T., Kleenmann, L., Jeżowski, J., Dobosz, D., Rawski, M., Indyka, P., Ważny, G., Mehta, R., Chramiec-Głąbik, A., Koziej, L., Ranff, T., Fufezan, C., Wawro, M., Kochan, J., Bereta, J., Leidel, S.A., Glatt, S.
The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
In: Molecular Cell. 2024
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