Designed DNA/Lipids

Centre for Programmable Biological Matter

Heddle Lab

DNA is not just an information storage molecule it is also a highly programmable structural material that can be easily designed to form useful shapes and even programmable robots. In our lab we harness this potential of DNA and combine in with other biomolecules like lipids and protein to produce nanoscale devices capable of various functions including biological material manipulation, motion, and modulation of immune system.

Designed DNA/Lipids publications:

Naskalska A, Heddle JG. Virus-like particles derived from bacteriophage MS2 as antigen scaffolds and RNA protective shells.
In: Nanomedicine (Lond). 2024
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Stępień P, Świątek S, Robles MYY, Markiewicz-Mizera J, Balakrishnan D, Inaba-Inoue S, De Vries AH, Beis K, Marrink SJ, Heddle JG. CRAFTing Delivery of Membrane Proteins into Protocells using Nanodiscs.
In: ACS Appl Mater Interfaces. 2023
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Shah SN, Heddle JG, Evans DJ, Lomonossoff GP. Production of Metallic Alloy Nanowires and Particles Templated Using Tomato Mosaic Virus (ToMV).
In: Nanomaterials (Basel). 2023
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Sakai Y, Wilkens GD, Wolski K, Zapotoczny S, Heddle JG. Topogami: Topologically Linked DNA Origami.
In: ACS Nanosci Au. 2022
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Islam, M. S., Wilkens, G. D., Wolski, K., Zapotoczny, S., Heddle, J. G.* (2021). Chiral 3D DNA origami structures for ordered heterologous arrays
In: Nanoscale Adv.
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Piette BMAG, Heddle JG. A Peptide-Nucleic Acid Replicator Origin for Life.
In: Trends Ecol Evol. 2020
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