Just published! – ‘Mechanistic insight into the pseudouridylation of RNA’

We are proud to share that our Assistant Professor, Ting-Yu Lin, and PhD student, Yasmin Stone, have co-authored a new review article in RNA Biology with Professor Sebastian Glatt from the Malopolska Centre of Biotechnology!

Titled ‘Mechanistic insight into the pseudouridylation of RNA’, this review explores how pseudouridylation (Ψ), one of the most abundant RNA modifications, shapes RNA structure, stability and function across all domains of life. The article provides a detailed overview of the enzymes responsible for Ψ, namely pseudouridine synthases (PUS), highlighting their diverse structures, precise catalytic mechanisms and remarkable substrate selectivity.

The article also delves into the biological significance of pseudouridylation in processes ranging from gene regulation to disease, and discusses how dysregulation of PUS activity has been linked to conditions such as neurodevelopmental disorders, mitochondrial diseases, and cancer. Importantly, the review examines recent structural and biochemical advances that could pave the way for novel RNA-targeted therapeutic strategies.

Read the full publication here: https://doi.org/10.1080/15476286.2025.2541421