2018

Centre for Programmable Biological Matter

2018

  • Sakai, Y., Islam, M. S., Adamiak, M., Shiu, S.C.-C., Tanner, J. A., Heddle, J. G., (2018) DNA Aptamers for the Functionalisation of DNA Origami Nanostructures, Genes 9, pp. 571 [MDPI]
    A summary of how DNA aptamers have been used alongside DNA origami.
  • Shiu, S.C.-C., Kinghorn, A.B., Sakai, Y., Cheung, Y-W., Heddle, J.G., Tanner, J.A. (2018) The Three S’s for Aptamer‐Mediated Control of DNA Nanostructure Dynamics: Shape, Self‐Complementarity, and Spatial Flexibility, ChemBioChem 19, pp. 1900-1906 [Wiley]
    A guide for designing aptamers to work with DNA origami.
  • Tang, M. S., Shiu, S. C-C., Godonoga, M., Cheung, Y-W., Liang, S., Dirkzwager, R. M., Kinghorn, A. B., Fraser, L. A., Heddle, J. G.*, Tanner, J. A.* (2018) An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine 14(4), pp. 1161-1168 [Elsevier]
    We show that the opening and closing of a DNA origami box can be controlled by molecular locks that respond to a malarial diagnostic signal.
  • Banwell, E. F., Piette, B., Taormina, A., Heddle, J. G. (2018) Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator, Molec. Biol. Evol. 35 404-416. [OUP] Before cells there were simple molecular replicators. What were they made of? A popular theory (RNA World) suggests that the initial replicators were RNA. Peptides have also been suggested as candidates. Here we demonstrate that, just like in todays cells, the initial replicator could have had a nucleic acid andi> a peptide component